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. 2008 Nov 7:8:324.
doi: 10.1186/1471-2407-8-324.

Important prognostic factors for the long-term survival of lung cancer subjects in Taiwan

Tai-An Chiang  1 , Ping-Ho Chen, Pei-Fen Wu, Tsu-Nai Wang, Po-Ya Chang, Albert Min-Shan Ko, Ming-Shyan Huang, Ying-Chin Ko
Affiliations

Important prognostic factors for the long-term survival of lung cancer subjects in Taiwan

Tai-An Chiang et al. BMC Cancer. .

Abstract

Background: This study used a large-scale cancer database in determination of prognostic factors for the survival of lung cancer subjects in Taiwan.

Methods: Total of 24,910 subjects diagnosed with lung cancer was analysed. Survival estimates by Kaplan-Meier methods. Cox proportional-hazards model estimated the death risk (hazard ratio (HR)) for various prognostic factors.

Results: The prognostic indicators associated with a higher risk of lung cancer deaths are male gender (males versus females; HR = 1.07, 95% confidence intervals (CI): 1.03-1.11), males diagnosed in later periods (shown in 1991-1994 versus 1987-1990; HR = 1.13), older age at diagnosis, large cell carcinoma (LCC)/small cell carcinoma (SCC), and supportive care therapy over chemotherapy. The overall 5-year survival rate for lung cancer death was significantly poorer for males (21.3%) than females (23.6%). Subjects with squamous cell carcinoma (SQCC) and treatment by surgical resection alone had better prognosis. We find surgical resections to markedly increase 5-year survival rate from LCC, decreased risk of death from LCC, and no improved survival from SCC.

Conclusion: Gender and clinical characteristics (i.e. diagnostic period, diagnostic age, histological type and treatment modality) play important roles in determining lung cancer survival.

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Figures

Figure 1
Figure 1
Survival curves for gender according to lung cancer death (N = 17229, p < 0.0001) as the endpoints.
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