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Review
. 2008 Nov;35(4):687-701; ix.
doi: 10.1016/j.ucl.2008.07.007.

Systemic therapy for metastatic renal cell carcinoma

Glenn S Kroog  1 , Robert J Motzer
Affiliations
Review

Systemic therapy for metastatic renal cell carcinoma

Glenn S Kroog et al. Urol Clin North Am. 2008 Nov.

Abstract

Renal cell cancer (RCC) is the most common form of cancer of the kidney and accounts for approximately 44,000 cases per year in the United States. Historically, only immunotherapy showed activity in metastatic RCC. The improved survival and quality of life for patients with metastatic RCC over the last several years are direct results of advances made in understanding the development of RCC. Three targeted therapies-sunitinib, sorafenib, and temsirolimus-have been approved for use in the United States recently. Current research is aimed at developing new drugs and combining available drugs to improve upon the responses and survival seen with approved single agents.

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