Influence of environmental viral agents on frequency and tempo of diabetes mellitus in BB/Wor rats
- PMID: 1899407
- DOI: 10.2337/diab.40.2.259
Influence of environmental viral agents on frequency and tempo of diabetes mellitus in BB/Wor rats
Abstract
Elimination of environmental viruses by cesarean derivation of the University of Massachusetts colony of BB/Wor rats increased the frequency and accelerated the tempo of spontaneous diabetes among diabetes-prone (DP) rats. In contrast, the viral-antibody-free (VAF) environment did not alter the resistance of pre-VAF diabetes-resistant (DR) rats to spontaneous and RT6+ T-lymphocyte-depletion-induced diabetes. Pre-VAF and VAF rats have essentially the same lymphocyte subsets, and VAF-DP rats are susceptible to the adoptive transfer of diabetes and to the diabetes-accelerating effects of polyinosinic-polycytidylic acid injections. These results suggest that the presence of environmental viral pathogens may act to inhibit effector cell function in lymphopenic DP rats while enhancing effector cell activity in nonlymphopenic DR rats.
Similar articles
-
Altered expression of diabetes in BB/Wor rats by exposure to viral pathogens.Diabetes. 1991 Feb;40(2):255-8. doi: 10.2337/diab.40.2.255. Diabetes. 1991. PMID: 1703973
-
Poly I:C induces development of diabetes mellitus in BB rat.Diabetes. 1992 Apr;41(4):515-20. doi: 10.2337/diab.41.4.515. Diabetes. 1992. PMID: 1535056
-
T-lymphocyte requirement for diabetes in RT6-depleted diabetes-resistant BB rats.Diabetes. 1991 Apr;40(4):423-8. doi: 10.2337/diab.40.4.423. Diabetes. 1991. PMID: 1707018
-
The T cell marker RT6 in a rat model of autoimmune diabetes.Adv Exp Med Biol. 1997;419:209-16. doi: 10.1007/978-1-4419-8632-0_26. Adv Exp Med Biol. 1997. PMID: 9193656 Review. No abstract available.
-
The BB/Wor rat and the balance hypothesis of autoimmunity.Diabetes Metab Rev. 1996 Jul;12(2):103-9. doi: 10.1002/(SICI)1099-0895(199607)12:2<103::AID-DMR161>3.0.CO;2-2. Diabetes Metab Rev. 1996. PMID: 8877279 Review. No abstract available.
Cited by
-
Anti-CD2 monoclonal antibodies prevent spontaneous and adoptive transfer of diabetes in the BB/Wor rat.Am J Pathol. 1992 Nov;141(5):1043-51. Am J Pathol. 1992. PMID: 1359788 Free PMC article.
-
Conventional housing conditions attenuate the development of experimental autoimmune encephalomyelitis.PLoS One. 2014 Jun 11;9(6):e99794. doi: 10.1371/journal.pone.0099794. eCollection 2014. PLoS One. 2014. PMID: 24919069 Free PMC article.
-
Lymphocyte subset abnormalities, autoantibodies and their relationship with HLA DR types in children with type 1 (insulin-dependent) diabetes and their first degree relatives.Diabetologia. 1994 Feb;37(2):155-65. doi: 10.1007/s001250050087. Diabetologia. 1994. PMID: 8163049
-
Possible role of macrophage-derived soluble mediators in the pathogenesis of encephalomyocarditis virus-induced diabetes in mice.J Virol. 1997 May;71(5):4024-31. doi: 10.1128/JVI.71.5.4024-4031.1997. J Virol. 1997. PMID: 9094680 Free PMC article.
-
Specific pathogen-free status alters immunophenotype in rhesus macaques: implications for the study of simian immunodeficiency virus.AIDS Res Hum Retroviruses. 2011 Oct;27(10):1033-42. doi: 10.1089/AID.2010.0155. Epub 2011 Apr 3. AIDS Res Hum Retroviruses. 2011. PMID: 21391843 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
