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Comparative Study
. 2008 Dec;20(10):721-6.
doi: 10.1016/j.clon.2008.09.004.

Estimation of renal function -- what is appropriate in cancer patients?

L H Barraclough  1 , C Field, G Wieringa, R Swindell, J E Livsey, S E Davidson
Affiliations
Comparative Study

Estimation of renal function -- what is appropriate in cancer patients?

L H Barraclough et al. Clin Oncol (R Coll Radiol). 2008 Dec.

Abstract

Aims: To compare the accuracy of renal assessment in patients with cancer using radioisotope glomerular filtration rate (GFR), urine collection for creatinine clearance, Cockroft-Gault, Modification of Diet in Renal Disease (MDRD) and Wright formulae.

Materials and methods: Measurements of isotope GFR from 367 patients were compared with estimates from the described methods (Cockroft-Gault, MDRD, Wright). An analysis including a further 252 patients with an isotope GFR < or = 50 ml/min was also carried out.

Results: The Wright formula was the most accurate form of estimating renal function for the first study group. The formulae were similar in accuracy in the second study group.

Conclusions: The Wright formula is the most accurate form of estimation of renal function in comparison with the isotope GFR for cancer patients. When there is a large proportion of patients with a low isotope GFR (< or = 50 ml/min), the formulae have similar accuracy.

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