doi: 10.1016/j.neures.2008.10.006.
Epub 2008 Oct 18.
Trifluoromethoxy-benzylated ligands improve amyloid detection in the brain using (19)F magnetic resonance imaging
Affiliations
- PMID: 18996420
- DOI: 10.1016/j.neures.2008.10.006
Item in Clipboard
Trifluoromethoxy-benzylated ligands improve amyloid detection in the brain using (19)F magnetic resonance imaging
Neurosci Res.
2009 Jan.
Abstract
The chemical properties of probes that improve amyloid detection by non-invasive (19)F magnetic resonance imaging (MRI) are of interest. We synthesized benzoxazole compounds with trifluoromethoxy groups, and found that these compounds displayed sharp (19)F nuclear magnetic resonance (NMR) signals in an assay buffer. However, the intensities of the (19)F NMR signals were dramatically reduced in mouse brain lysates. Our results indicate that the inhibitory effect of brain tissue on the (19)F NMR signals from these probes can be attributed to the hydrophobicity of the tissue. These results highlight the importance of using hydrophilic (19)F-MRI agents to avoid the inhibitory effects of brain tissues on (19)F NMR signals.
Similar articles
-
Styryl-based compounds as potential in vivo imaging agents for beta-amyloid plaques.Chembiochem. 2007 Sep 24;8(14):1679-87. doi: 10.1002/cbic.200700154. Chembiochem. 2007. PMID: 17705341
-
Structure-activity relationship of chalcones and related derivatives as ligands for detecting of beta-amyloid plaques in the brain.Bioorg Med Chem. 2007 Oct 1;15(19):6388-96. doi: 10.1016/j.bmc.2007.06.055. Epub 2007 Jul 4. Bioorg Med Chem. 2007. PMID: 17644339
-
Development of novel beta-amyloid probes based on 3,5-diphenyl-1,2,4-oxadiazole.Bioorg Med Chem. 2008 Jul 15;16(14):6867-72. doi: 10.1016/j.bmc.2008.05.054. Epub 2008 May 29. Bioorg Med Chem. 2008. PMID: 18550375
-
Amyloid imaging using fluorine-19 magnetic resonance imaging ((19)F-MRI).Ageing Res Rev. 2016 Sep;30:85-94. doi: 10.1016/j.arr.2015.12.008. Epub 2016 Jan 6. Ageing Res Rev. 2016. PMID: 26772439 Review.
-
MR spectroscopy of Alzheimer disease.Radiol Technol. 1998 Sep-Oct;70(1):23-8. Radiol Technol. 1998. PMID: 9779506 Review.
Cited by
-
Fluorine-19 Magnetic Resonance Imaging for Detection of Amyloid β Oligomers Using a Keto Form of Curcumin Derivative in a Mouse Model of Alzheimer's Disease.Molecules. 2021 Mar 4;26(5):1362. doi: 10.3390/molecules26051362. Molecules. 2021. PMID: 33806326 Free PMC article.
-
Molecular Imaging of Fluorinated Probes for Tau Protein and Amyloid-β Detection.Molecules. 2020 Jul 28;25(15):3413. doi: 10.3390/molecules25153413. Molecules. 2020. PMID: 32731418 Free PMC article. Review.
-
A Novel Liposomal Nanoparticle for the Imaging of Amyloid Plaque by Magnetic Resonance Imaging.J Alzheimers Dis. 2016;52(2):731-45. doi: 10.3233/JAD-151124. J Alzheimers Dis. 2016. PMID: 27031484 Free PMC article.
-
Neuroprotective Effects of Casein-Derived Peptide Met-Lys-Pro (MKP) in a Hypertensive Model.Front Neurosci. 2020 Aug 14;14:845. doi: 10.3389/fnins.2020.00845. eCollection 2020. Front Neurosci. 2020. PMID: 32922259 Free PMC article.
-
Magnetic Resonance Imaging in Animal Models of Alzheimer's Disease Amyloidosis.Int J Mol Sci. 2021 Nov 25;22(23):12768. doi: 10.3390/ijms222312768. Int J Mol Sci. 2021. PMID: 34884573 Free PMC article. Review.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
