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. 2008 Dec;40(12):1402-3.
doi: 10.1038/ng.251. Epub 2008 Nov 9.

Genetic variation in the KIF1B locus influences susceptibility to multiple sclerosis

Yurii S Aulchenko  1 , Ilse A Hoppenbrouwers, Sreeram V Ramagopalan, Linda Broer, Naghmeh Jafari, Jan Hillert, Jenny Link, Wangko Lundström, Eva Greiner, A Dessa Sadovnick, Dirk Goossens, Christine Van Broeckhoven, Jurgen Del-Favero, George C Ebers, Ben A Oostra, Cornelia M van Duijn, Rogier Q Hintzen
Affiliations

Genetic variation in the KIF1B locus influences susceptibility to multiple sclerosis

Yurii S Aulchenko et al. Nat Genet. 2008 Dec.

Abstract

The few loci associated with multiple sclerosis (MS) are all related to immune function. We report a GWA study identifying a new locus replicated in 2,679 cases and 3,125 controls. An rs10492972[C] variant located in the KIF1B gene was associated with MS with an odds ratio of 1.35 (P = 2.5 x 10(-10)). KIF1B is a neuronally expressed gene plausibly implicated in the irreversible axonal loss characterizing MS in the long term.

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Comment in

  • Lack of support for association between the KIF1B rs10492972[C] variant and multiple sclerosis.
    International Multiple Sclerosis Genetics Consortium (IMSGC); Booth DR, Heard RN, Stewart GJ, Cox M, Scott RJ, Lechner-Scott J, Goris A, Dobosi R, Dubois B, Saarela J, Leppä V, Peltonen L, Pirttila T, Cournu-Rebeix I, Fontaine B, Bergamaschi L, D'Alfonso S, Leone M, Lorentzen AR, Harbo HF, Celius EG, Spurkland A, Link J, Kockum I, Olsson T, Hillert J, Ban M, Baker A, Kemppinen A, Sawcer S, Compston A, Robertson NP, De Jager PL, Hafler DA, Barcellos LF, Ivinson AJ, McCauley JL, Pericak-Vance MA, Oksenberg JR, Hauser SL, Sexton D, Haines J. International Multiple Sclerosis Genetics Consortium (IMSGC), et al. Nat Genet. 2010 Jun;42(6):469-70; author reply 470-1. doi: 10.1038/ng0610-469. Nat Genet. 2010. PMID: 20502484 Free PMC article. No abstract available.

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