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Comment
. 2008 Dec;128(12):2745-7.
doi: 10.1038/jid.2008.330.

Rituximab immunotherapy in pemphigus: therapeutic effects beyond B-cell depletion

Giovanna Zambruno  1 , Luca Borradori
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Free article
Comment

Rituximab immunotherapy in pemphigus: therapeutic effects beyond B-cell depletion

Giovanna Zambruno et al. J Invest Dermatol. 2008 Dec.
Free article

Abstract

The anti-CD20 mAb rituximab, first approved for use in B-cell malignancies, is increasingly used to treat a variety of autoimmune diseases. Two studies in this issue investigate the effects of rituximab in pemphigus. Rituximab induces not only a depletion of all B cells and a decline of antidesmoglein autoantibodies but also a decrease in desmoglein-specific T cells. Furthermore, B-cell populations recovered after treatment were modified. These novel aspects may contribute to the clinical responses observed in patients.

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