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Case Reports
. 2008 Nov-Dec;22(6):1427-31.
doi: 10.1111/j.1939-1676.2008.0203.x.

Congenital thyroid hypoplasia and seizures in 2 littermate kittens

A M Traas  1 , B L Abbott, A French, U Giger
Affiliations
Case Reports

Congenital thyroid hypoplasia and seizures in 2 littermate kittens

A M Traas et al. J Vet Intern Med. 2008 Nov-Dec.

Erratum in

  • J Vet Intern Med. 2009 Jan-Feb;23(1):225
No abstract available

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Figures

Fig 1
Fig 1
Photographs of affected littermate kittens. Kitten A (photos A and B) and Kitten B (photos C and D) at 14 weeks of age. Note the disproportionate dwarfism typical of cretinism.
Fig 2
Fig 2
Radiographs of Kitten A at 14 weeks of age. Note the wide growth plates with delayed ossification. Vertebral bodies (photos A and D) are widened and square. Carpal (photo C) and tarsal (photo D) bones also have delayed ossification. Megacolon (A,D) and a fracture of a sternebrae through the growth plate (D) can also be seen.
Fig 3
Fig 3
Gross pathology of Kitten B cervical region. On postmortem examination severely hypoplastic thyroid glands were paper-thin, pale brown, and indistinct from surrounding tissues (arrow).
Fig 4
Fig 4
Histopathology of normal and affected thyroid glands. Histology at 2 different magnifications, showing a normal age-matched thyroid gland (A, C) compared with an affected thyroid gland (B, D). Follicles in the affected glands are decreased in both density and size.
See this image and copyright information in PMC

References

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    1. Sjollema BE, den Hartog MT, de Vijlder JJ, et al. Congenital hypothyroidism in two cats due to defective organification: Data suggesting loosely anchored thyroperoxidase. Acta Endocrinol (Copenhagen) 1991;125:435–440. - PubMed
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