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. 2009 Apr;50 Suppl(Suppl):S249-54.
doi: 10.1194/jlr.R800072-JLR200. Epub 2008 Nov 11.

Phosphoinositide phosphatases and disease

Philip W Majerus  1 , John D York
Affiliations

Phosphoinositide phosphatases and disease

Philip W Majerus et al. J Lipid Res. 2009 Apr.

Abstract

The field of inositol signaling has expanded greatly in recent years. Given the many reviews on phosphoinositide kinases, we have chosen to restrict our discussion to inositol lipid hydrolysis focused on the phosphatases and a brief mention of the lipase isoforms. We also discuss recent discoveries that link mutations in phosphoinositide phosphatases to disease.

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Figures

Fig. 1.
Fig. 1.
Inositol lipid regulatory pathways. Seven individual phosphoinositides comprise a “lipid code”. Forward and reverse arrows indicate kinase and phosphatase reactions. Nomenclature of PIxPn: x designates the inositol ring positions that are phosphorylated, whereas n refers to the total number phosphomonoesters.
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