[Coronary arteritis induced by CAWS (Candida albicans water-soluble fraction) in various strains of mice]

Abstract

The intraperitoneal administration of CAWS (water-soluble extracellular polysaccharide fraction obtained from the culture supernatant of Candida albicans NBRC 1385) to mice induces coronaritis similar to Kawasaki disease. We analyzed differences in the occurrence of coronary arteritis among mouse strains, inbred strains, a closed colony, hybrids and mutants. CAWS vasculitis was induced in almost all of the inbred and closed colony strains tested, except for CBA / J mice; it was induced also in hybrids, CDF1 and BDF1. In mutant strains of various immunological defects, such as C57BL / 6J Ham Slc-bg , Balb / c nu / nu , C.B.17 / Icr-scid / scid , WBB6F1-W / W (v) mice, all induced CAWS vasculitis but a relatively weak phenotype. It has already been postulated that CAWS vasculitis is regulated by various genes, those related to acute as well as chronic inflammation. This might well reflect the clinical situation in human disease.