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Review
. 2009 Jan 13;100(1):1-7.
doi: 10.1038/sj.bjc.6604767. Epub 2008 Nov 11.

Antiangiogenic drugs in ovarian cancer

G C Kumaran  1 , G C Jayson, A R Clamp
Affiliations
Review

Antiangiogenic drugs in ovarian cancer

G C Kumaran et al. Br J Cancer. .

Abstract

Ovarian cancer continues to be a major cause of morbidity and mortality in women. Antiangiogenic treatments have emerged as a promising strategy to treat ovarian cancer. This article reviews the rationale supporting the use of antiangiogenic treatments in ovarian cancer, the clinical development of this group of drugs and the toxicities specific to this modality of treatment.

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Figures

Figure 1
Figure 1
Strategies to inhibit the VEGF signalling pathway. Neuropilins (NRs) can function as co-receptors for vascular endothelial growth factor receptor (VEGFR). VEGF Trap (decoy receptor), growth factor-binding domains of VEGFR-1 and -2 bound to Fc fragment of IgG, and tyrosine kinase inhibitors (TKIs) prevent phosphorylation of VEGFR in response to VEGF binding. Delta-like ligand-4 (DLL4) binds to the Notch receptor, which leads to the cleavage of the Notch intracellular domain (NCID). The cleaved NCID translocates to the nucleus leading to the transcription of notch target genes. Protein kinase C (PKC) family of kinases are downstream mediators of VEGFR signalling. PlGF=placental-like growth factor.
See this image and copyright information in PMC

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