Distinctive features of foreskin condylomata acuminata associated with diabetes mellitus

Abstract

The aim of this study was to test the hypothesis that particular clinical features of foreskin condylomata acuminata in Chinese male patients are associated with diabetes. A prospective study enrolled 126 men presenting with foreskin condylomata acuminata from 2001 to 2006. Mean age was 46 years (age range 25-74 years) and mean duration of disease was 4.8 months (range 1-18 months). Patients were divided into two groups according to clinical features. In group 1, 42 men had distinctive signs such as redundant prepuce, crown warts circling the entire preputial ring, maceration, fissures, phimosis and balanitis, and 37 of 42 (88%) patients were found to have concurrent type 2 diabetes, furthermore 32 of these 37 patients had an insidious onset and were previously undiagnosed. In group 2, 84 male patients did not have those distinctive clinical features and type 2 diabetes was found in only 10 cases (11.9%, p<0.0001, Fisher's exact test). These clinical features strongly suggest the presence of diabetes. Therapy should address diabetes and condylomata concurrently.

Fig. 1

(A) Group 1 patient 13 with condylomata acuminata for 5 months. The warts presented as exophytic growths circling the preputial ring. Phimosis and candidal balanitis was present. (B) Group 1 patient 4 with condylomata acuminata for 1 month. The warts circled the preputial ring and phimosis can be seen. (C) Group 1 patient 19 with condylomata acuminata for 5 months. The warts presented as exophytic growths circling the preputial ring. Phimosis was present. Maceration, fissures and bleeding on the prepuce and candidal balanitis could be observed. (D) Group 2 patient with condylomata acuminata for 2 months. The warts were located only on the frenulum. (E) Group 2 patient with condylomata acuminata for 8 months. The warts were randomly distributed on the penis. (F) Group 2 patient with condylomata acuminata for 4 months. One large wart covered the coronal sulcus.