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Review
. 2008 Dec;13(4):407-13.
doi: 10.1007/s10911-008-9097-1. Epub 2008 Nov 11.

The impact of transgenic IGF-IR overexpression on mammary development and tumorigenesis

Robert A Jones  1 , Roger A Moorehead
Affiliations
Review

The impact of transgenic IGF-IR overexpression on mammary development and tumorigenesis

Robert A Jones et al. J Mammary Gland Biol Neoplasia. 2008 Dec.

Abstract

Insulin-like growth factor-I and -II (IGF-I and IGF-II) and/or the type I insulin-like growth factor receptor (IGF-IR) have been implicated in a number of human tumors including breast cancer. However, despite being implicated in breast cancer for approximately 25 years and given that transgenic technology has been available for about the same period of time, it is surprising that transgenic mice overexpressing the IGF-IR in the mammary gland have only recently been characterized. This review will describe the effects of IGF-IR overexpression on mammary ductal morphogenesis and mammary tumorigenesis in the two available transgenic models.

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