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. 1998 Sep;27(1-3):137-48.
doi: 10.1023/A:1008004502861.

Vault-related resistance to anticancer drugs determined by the expression of the major vault protein LRP

M A Izquierdo  1 , G L Scheffer, A B Schroeijers, M C de Jong, R J Scheper
Affiliations

Vault-related resistance to anticancer drugs determined by the expression of the major vault protein LRP

M A Izquierdo et al. Cytotechnology. 1998 Sep.

Abstract

In this review we analyze the data supporting the notion that vault-related MDR, as reflected by LRP/MVP overexpression, represents a marker of drug resistance in vitro and in the clinic. Vaults, besides playing a fundamental biological role, may be involved in a novel mechanism of MDR.

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