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. 1998 Sep;27(1-3):293-308.
doi: 10.1023/A:1008058031511.

Apoptosis resistance in tumor cells

T Mashima  1 , H Seimiya, Z Chen, S Kataoka, T Tsuruo
Affiliations

Apoptosis resistance in tumor cells

T Mashima et al. Cytotechnology. 1998 Sep.

Abstract

Various antitumor agents induce apoptotic cell death in tumor cells. Since the apoptosis program in tumor cells plays a critical role in the chemotherapy-induced tumor cell killing, it is suggested that the defect in the signaling pathway of apoptosis could cause a new form of multidrug resistance in tumor cells. This article describes the recent findings concerning the mechanisms of chemotherapy-induced apoptosis and discusses the implication of apoptosis resistance in cancer chemotherapy.

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