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. 2008 Feb;56(2):137-44.
doi: 10.1007/s10616-008-9137-0. Epub 2008 Feb 21.

Clastogenic effects of food additive citric acid in human peripheral lymphocytes

Serkan Yılmaz  1 , Fatma Unal, Deniz Yüzbaşıoğlu, Hüseyin Aksoy
Affiliations

Clastogenic effects of food additive citric acid in human peripheral lymphocytes

Serkan Yılmaz et al. Cytotechnology. 2008 Feb.

Abstract

Clastogenic properties of the food additive citric acid, commonly used as an antioxidant, were analysed in human peripheral blood lymphocytes. Citric acid induced a significant increase of chromosomal aberrations (CAs) at all the concentrations and treatment periods tested. Citric acid significantly decreased mitotic index (MI) at 100 and 200 mug ml(-1) concentrations at 24 h, and in all concentrations at 48 h. However, it did not decrease the replication index (RI) significantly. Citric acid also significantly increased sister chromatid exchanges (SCEs) at 100 and 200 mug ml(-1) concentrations at 24 h, and in all concentrations at 48 h. This chemical significantly increased the micronuclei frequency (MN) compared to the negative control. It also decreased the cytokinesis-block proliferation index (CBPI), but this result was not statistically significant.

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References

    1. None
    2. Aktaç T, Kaboğlu A, Ertan F, Ekinci F, Huseyinova G (2003) The effects of citric acid [antioxidant] and benzoic acid [antimicrobial agent] on the mouse liver: biochemical and histopatological study. Biologia Bratisl 58:343–347
    1. {'text': '', 'ref_index': 1, 'ids': [{'type': 'DOI', 'value': '10.1016/S1383-5742(00)00049-1', 'is_inner': False, 'url': 'https://doi.org/10.1016/s1383-5742(00)00049-1'}, {'type': 'PubMed', 'value': '10913908', 'is_inner': True, 'url': 'https://pubmed.ncbi.nlm.nih.gov/10913908/'}]}
    2. Albertini RJ, Aderson D, Dauglas GR, Hagmar L, Hemminki K, Merlo F, Natarajan AT, Norppa H, Shuker DEG, Tice R, Waters MD, Atio A (2000) IPCS guidelines for the monitoring of genotoxic effects of carcinogens in human. Mutat Res 463:111–172 - PubMed
    1. {'text': '', 'ref_index': 1, 'ids': [{'type': 'PMC', 'value': 'PMC369669', 'is_inner': False, 'url': 'https://pmc.ncbi.nlm.nih.gov/articles/PMC369669/'}, {'type': 'PubMed', 'value': '6965099', 'is_inner': True, 'url': 'https://pubmed.ncbi.nlm.nih.gov/6965099/'}]}
    2. Ashman CR, Davidson RL (1981) Bromodeoxyuridine mutagenesis in mammalian cells is related to deoxyribonucleotide pool imbalance. Mol Cell Biol 1:254–260 - PMC - PubMed
    1. {'text': '', 'ref_index': 1, 'ids': [{'type': 'PubMed', 'value': '14644360', 'is_inner': True, 'url': 'https://pubmed.ncbi.nlm.nih.gov/14644360/'}]}
    2. Blasczyk A, Osiecka R, Skolimowski J (2003) Induction of chromosome aberrations in cultured human lymphocytes treated with ethoxyquin. Mutat Res 542:117–128 - PubMed
    1. {'text': '', 'ref_index': 1, 'ids': [{'type': 'DOI', 'value': '10.1016/S1383-5742(03)00015-2', 'is_inner': False, 'url': 'https://doi.org/10.1016/s1383-5742(03)00015-2'}, {'type': 'PubMed', 'value': '12787816', 'is_inner': True, 'url': 'https://pubmed.ncbi.nlm.nih.gov/12787816/'}]}
    2. Bolognesi C (2003) Genotoxicity of pesticides: a review of human biomonitoring studies. Mutat Res 543:251–272 - PubMed