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. 2003 Nov;43(1-3):127-34.
doi: 10.1023/b:cyto.0000039899.67160.18.

Estrogenic and Acetylcholinesterase-Enhancement Activity of a New Isoflavone, 7,2',4'-Trihydroxyisoflavone-4'-O-beta-D-Glucopyranoside from Crotalaria Sessililflora

Abdul Mun'im  1 , Hiroko Isoda, Mariko Seki, Osamu Negishi, Tetsuo Ozawa
Affiliations

Estrogenic and Acetylcholinesterase-Enhancement Activity of a New Isoflavone, 7,2',4'-Trihydroxyisoflavone-4'-O-beta-D-Glucopyranoside from Crotalaria Sessililflora

Abdul Mun'im et al. Cytotechnology. 2003 Nov.

Abstract

A new isoflavone, 7,2',4'-trihydroxyisoflavone-4'-O-beta-D-glucopyranoside has been isolated from the aerial part of Crotalaria sessiliflora. The isoflavone glucoside enhanced the proliferation of the MCF-7 human breast cancer cell line, which possesses estrogen receptor (ER) and responds to estrogen in culture. The estrogenic property of the isoflavone glucoside was blocked by the known ER antagonist tamoxifen, indicating the involvement of the ER. Furthermore, the isoflavone glucoside was found to enhance the acetylcholinesterase (AChE) activity of the rat neuronal cell line PC12 at low concentrations of nerve growth factor (NGF).

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References

    1. Adesanya S.A., O'Neill M.J., Robert M.F. Induced and constitutive iso.avonoids in Phaseolus mungo L.Legu-minosae. Z.Naturforch. 1984;39:888–893.
    1. Agrawal P.K. NMR spectroscopy in the structural elu-cidation of oligosaccharides and glycosides. Phytochemistry. 1992;31:3307–3330. doi: 10.1016/0031-9422(92)83678-R. - DOI - PubMed
    1. Deodato B., Altavilla D., Squadrito G., Campo G.M., Arlotta M., Minutoli L., Saitta A., Cucinotta D., Calapai G., Caputi A.P., Miano M., Squadrito F. Cardioprotection by the phytoestrogen genistein in experimental myocardial ischaemia-reperfusion injury. Br.J.Pharm. 1999;128:1683–1690. doi: 10.1038/sj.bjp.0702973. - DOI - PMC - PubMed
    1. Greene L., Rukenstein A. Regulation of acetyl-cholinesterase activity by nerve growth factor. J.Biol.Chem. 1981;256:6363–6367. - PubMed
    1. Han D.H., Denison M.S., Tachibana H., Yamada K. Relationship between estrogen receptor-binding and estro-genic activities of environmental estrogens and suppression by flavonoids. Biosci.Biotechnol.Biochem. 2002;66:1479–1487. doi: 10.1271/bbb.66.1479. - DOI - PubMed