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. 2008 Jun;2(2):115-20.
doi: 10.1007/s11571-008-9044-2. Epub 2008 Apr 23.

Cortical network dynamics with time delays reveals functional connectivity in the resting brain

A Ghosh  1 , Y Rho, A R McIntosh, R Kötter, V K Jirsa
Affiliations

Cortical network dynamics with time delays reveals functional connectivity in the resting brain

A Ghosh et al. Cogn Neurodyn. 2008 Jun.

Abstract

In absence of all goal-directed behavior, a characteristic network of cortical regions involving prefrontal and cingulate cortices consistently shows temporally coherent fluctuations. The origin of these fluctuations is unknown, but has been hypothesized to be of stochastic nature. In the present paper we test the hypothesis that time delays in the network dynamics play a crucial role in the generation of these fluctuations. By tuning the propagation velocity in a network based on primate connectivity, we scale the time delays and demonstrate the emergence of the resting state networks for biophysically realistic parameters.

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Figures

Fig. 1
Fig. 1
Characterization of the primate connectivity matrix: node wise degree distributions and clustering index
Fig. 2
Fig. 2
Integrated entropy for transmission speeds ∞, 15, 7, 3, and 2 m/s
Fig. 3
Fig. 3
Averaged wavelet power spectrum
Fig. 4
Fig. 4
The functional connectivity obtained from wavelet covariance matrix
See this image and copyright information in PMC

References

    1. Assisi CG, Jirsa VK, Kelso JAS (2005) Synchrony and clustering in heterogeneous networks with global coupling and parameter dispersion. PRL 94:018106 - PubMed
    1. {'text': '', 'ref_index': 1, 'ids': [{'type': 'DOI', 'value': '10.1016/j.tics.2007.05.005', 'is_inner': False, 'url': 'https://doi.org/10.1016/j.tics.2007.05.005'}, {'type': 'PubMed', 'value': '17548232', 'is_inner': True, 'url': 'https://pubmed.ncbi.nlm.nih.gov/17548232/'}]}
    2. Bar M (2007) The proactive brain: using analogies and associations to generate predictions. Trends Cogn Sci 11(7):280–289 - PubMed
    1. {'text': '', 'ref_index': 1, 'ids': [{'type': 'DOI', 'value': '10.1002/mrm.1910340409', 'is_inner': False, 'url': 'https://doi.org/10.1002/mrm.1910340409'}, {'type': 'PubMed', 'value': '8524021', 'is_inner': True, 'url': 'https://pubmed.ncbi.nlm.nih.gov/8524021/'}]}
    2. Biswal B, Yetkin FZ, Haughton VM, Hyde JS (1995) Functional connectivity in the motor cortex of resting human brain using echo-planar MRI. Magn Reson Med 34:537–541 - PubMed
    1. Breakspear M, Jirsa VK (2007) Neuronal dynamics and brain connectivity. In: Jirsa VK, McIntosh ARM (eds) Handbook of brain connectivity. Springer
    1. {'text': '', 'ref_index': 1, 'ids': [{'type': 'DOI', 'value': '10.1073/pnas.0601417103', 'is_inner': False, 'url': 'https://doi.org/10.1073/pnas.0601417103'}, {'type': 'PMC', 'value': 'PMC1564249', 'is_inner': False, 'url': 'https://pmc.ncbi.nlm.nih.gov/articles/PMC1564249/'}, {'type': 'PubMed', 'value': '16945915', 'is_inner': True, 'url': 'https://pubmed.ncbi.nlm.nih.gov/16945915/'}]}
    2. Damoiseaux JS et al (2006) Consistent resting-state networks across healthy subjects. Proc Natl Acad Sci USA 103:13848–13853 - PMC - PubMed