doi: 10.1016/0092-8674(91)90327-u.
Cellular immunity to HIV activated by CD4 fused to T cell or Fc receptor polypeptides
Affiliations
- PMID: 1900456
- DOI: 10.1016/0092-8674(91)90327-u
Item in Clipboard
Cellular immunity to HIV activated by CD4 fused to T cell or Fc receptor polypeptides
Cell.
.
Abstract
We describe functional simplified T cell and Fc receptor chimeras that are capable of directing CD8+ cytotoxic T lymphocytes (CTLs) to specifically recognize and lyse cells expressing HIV envelope proteins. Target cells bearing HLA-DR molecules are not recognized by CTL armed with the chimeras. The variety of cell types in which the native receptors are active suggests multiple possibilities for antiviral intervention through genetic means.
Similar articles
-
Bispecific antibodies that mediate killing of cells infected with human immunodeficiency virus of any strain.Proc Natl Acad Sci U S A. 1991 Jun 1;88(11):4723-7. doi: 10.1073/pnas.88.11.4723. Proc Natl Acad Sci U S A. 1991. PMID: 1905015 Free PMC article.
-
Cytotoxic T lymphocyte triggering via CD16 is regulated by CD3 and CD8 antigens. Studies with T cell receptor (TCR)-alpha beta+/CD3+16+ and TCR-gamma delta+/CD3+16+ granular lymphocytes.J Immunol. 1990 May 1;144(9):3312-7. J Immunol. 1990. PMID: 2139452
-
High avidity CD8+ T cells efficiently eliminate motile HIV-infected targets and execute a locally focused program of anti-viral function.PLoS One. 2014 Feb 13;9(2):e87873. doi: 10.1371/journal.pone.0087873. eCollection 2014. PLoS One. 2014. PMID: 24551068 Free PMC article.
-
CD4: collaborator in immune recognition and HIV infection.Cell. 1990 Mar 9;60(5):697-700. doi: 10.1016/0092-8674(90)90082-p. Cell. 1990. PMID: 2107022 Review. No abstract available.
-
Structure and expression of cloned Fc gamma receptors.Res Immunol. 1990 Jan;141(1):68-74; discussion 105-8. doi: 10.1016/0923-2494(90)90104-7. Res Immunol. 1990. PMID: 1693216 Review. No abstract available.
Cited by
-
Development of HIV-Resistant CAR T Cells by CRISPR/Cas-Mediated CAR Integration into the CCR5 Locus.Viruses. 2023 Jan 10;15(1):202. doi: 10.3390/v15010202. Viruses. 2023. PMID: 36680242 Free PMC article.
-
Adoptive Cell Transfer: Is it a Promising Immunotherapy for Colorectal Cancer?Theranostics. 2018 Nov 10;8(20):5784-5800. doi: 10.7150/thno.29035. eCollection 2018. Theranostics. 2018. PMID: 30555581 Free PMC article. Review.
-
Strategies for enhancing CAR T cell expansion and persistence in HIV infection.Front Immunol. 2023 Aug 21;14:1253395. doi: 10.3389/fimmu.2023.1253395. eCollection 2023. Front Immunol. 2023. PMID: 37671164 Free PMC article. Review.
-
Quarter Century of Anti-HIV CAR T Cells.Curr HIV/AIDS Rep. 2018 Apr;15(2):147-154. doi: 10.1007/s11904-018-0388-x. Curr HIV/AIDS Rep. 2018. PMID: 29500712 Free PMC article. Review.
-
Specific activation and targeting of cytotoxic lymphocytes through chimeric single chains consisting of antibody-binding domains and the gamma or zeta subunits of the immunoglobulin and T-cell receptors.Proc Natl Acad Sci U S A. 1993 Jan 15;90(2):720-4. doi: 10.1073/pnas.90.2.720. Proc Natl Acad Sci U S A. 1993. PMID: 8421711 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Research Materials
