[Methodological aspects on new protocols in oncology]
- PMID: 19004729
- DOI: 10.1684/bdc.2008.0732
[Methodological aspects on new protocols in oncology]
Abstract
This review will summarize specific methodological aspects in targeted therapies like EPR (early progression rate) or RDD (randomized discontinuation design), along with Adaptive Design such as CRM (continual reassessment method, Eff-TOX (dose-finding based on efficacy-toxicity, PPD (predictive probability design) or ADTT (adaptive randomization for targeted therapy) methods.
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