doi: 10.1016/0014-5793(91)80162-v.
Modulation of a Shaker potassium A-channel by protein kinase C activation
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- PMID: 1900473
- DOI: 10.1016/0014-5793(91)80162-v
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Modulation of a Shaker potassium A-channel by protein kinase C activation
FEBS Lett.
.
Free article
Abstract
Brain fast transient K+ channel (A channel) is known to be modulated by PKC activation. We studied, by two-electrode voltage clamp, the molecular mechanism of modulation by PKC activation of A-channels expressed in Xenopus oocytes from the Shaker H4 clone. The modulation is inhibitory affecting primarily the maximal conductance of the channels. A secondary effect is a small change in the voltage-dependence of activation and inactivation of the channel.
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