Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2008 Nov 12;28(46):11778-84.
doi: 10.1523/JNEUROSCI.3929-08.2008.

A double TRPtych: six views of transient receptor potential channels in disease and health

Robert A Cornell  1 , Michelle Aarts, Diana Bautista, Jaime García-Añoveros, Kirill Kiselyov, Emily R Liman
Affiliations
Review

A double TRPtych: six views of transient receptor potential channels in disease and health

Robert A Cornell et al. J Neurosci. .

Abstract

At the 2008 Annual Meeting of the Society for Neuroscience, a Mini-Symposium entitled "Contributions to TRP Channels to Neurological Disease" included talks from six heads of newly established laboratories, each with a unique research focus, model system, and set of experimental tools. Some of the questions addressed in these talks include the following. What is the role of transient receptor potential (TRP) channels in pain perception? How do normally functioning TRP channels contribute to cell death pathways? What are the characteristics of TRPpathies, disease states that result from overactive or underactive TRP channels? How are TRP channels regulated by signal transduction cascades? This review summarizes recent results from those laboratories and provides six perspectives on the subject of TRP channels and disease.

PubMed Disclaimer

References

    1. Aarts MM, Tymianski M. TRPM7 and ischemic CNS injury. Neuroscientist. 2005;11:116–123. - PubMed
    1. Aarts M, Iihara K, Wei WL, Xiong ZG, Arundine M, Cerwinski W, MacDonald JF, Tymianski M. A key role for TRPM7 channels in anoxic neuronal death. Cell. 2003;115:863–877. - PubMed
    1. Acharya JK, Jalink K, Hardy RW, Hartenstein V, Zuker CS. InsP3 receptor is essential for growth and differentiation but not for vision in Drosophila. Neuron. 1997;18:881–887. - PubMed
    1. Ambudkar IS. Trafficking of TRP channels: determinants of channel function. Handb Exp Pharmacol. 2007:541–557. - PubMed
    1. Andersson DA, Gentry C, Moss S, Bevan S. Transient receptor potential A1 is a sensory receptor for multiple products of oxidative stress. J Neurosci. 2008;28:2485–2494. - PMC - PubMed

Publication types

MeSH terms

Substances