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Comment
. 2008 Nov 13;456(7219):183-5.
doi: 10.1038/456183a.

Ion channels: The voltage-sensor quartet

J R Bankston, R S Kass
Comment

Ion channels: The voltage-sensor quartet

J R Bankston et al. Nature. .

Abstract

Decoding the workings of voltage-gated sodium channels is crucial because their mutation leads to severe disease and their activity is modulated by toxins and drugs. An innovative approach now allows such investigations.

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Figures

Figure 1
Figure 1. Chimaera channels
a, Studying voltage sensors of sodium channels has been difficult, partly because these channels are made from four domains, each with a unique voltage paddle. b, Bosman et al. describe a method for looking at voltage sensors of sodium channels in isolation by inserting each paddle in all four positions in a potassium channel. (Adapted from ref. 6.)
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References

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