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. 2008 Dec 7;6(23):4287-9.
doi: 10.1039/b814314e. Epub 2008 Oct 15.

Hyperstable miniproteins: additive effects of D- and L-Ala mutations

D Victoria Williams  1 , Bipasha Barua, Niels H Andersen
Affiliations

Hyperstable miniproteins: additive effects of D- and L-Ala mutations

D Victoria Williams et al. Org Biomol Chem. .

Abstract

The folding enantioselectivity for D-Ala versus L-Ala at one glycine site in the Trp-cage is 16 kJ mol(-1); judicious introductions of alanines of the correct chirality raises the melting temperature of this 20-residue fold to 83 degrees C.

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