doi: 10.1039/b814314e.
Epub 2008 Oct 15.
Hyperstable miniproteins: additive effects of D- and L-Ala mutations
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- PMID: 19005584
- DOI: 10.1039/b814314e
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Hyperstable miniproteins: additive effects of D- and L-Ala mutations
Org Biomol Chem.
.
Abstract
The folding enantioselectivity for D-Ala versus L-Ala at one glycine site in the Trp-cage is 16 kJ mol(-1); judicious introductions of alanines of the correct chirality raises the melting temperature of this 20-residue fold to 83 degrees C.
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