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Clinical Trial
. 2009 May;17(5):563-72.
doi: 10.1007/s00520-008-0528-8. Epub 2008 Nov 13.

Phase II trial of encapsulated ginger as a treatment for chemotherapy-induced nausea and vomiting

Suzanna M Zick  1 , Mack T Ruffin, Julia Lee, Daniel P Normolle, Rivka Siden, Sara Alrawi, Dean E Brenner
Affiliations
Clinical Trial

Phase II trial of encapsulated ginger as a treatment for chemotherapy-induced nausea and vomiting

Suzanna M Zick et al. Support Care Cancer. 2009 May.

Abstract

Goals of work: Ginger has been used to treat numerous types of nausea and vomiting. Ginger has also been studied for its efficacy for acute chemotherapy-induced nausea and vomiting (CINV). However, its efficacy for delayed CINV in a diverse oncology population is unknown.

Materials and methods: We performed a randomized, double-blind, placebo-controlled trial in 162 patients with cancer who were receiving chemotherapy and had experienced CINV during at least one previous round of chemotherapy. All participants were receiving a 5-HT3 receptor antagonists and/or aprepitant. Participants were randomized to receive either 1.0 g ginger, 2.0 g ginger daily, or matching placebo for 3 days. The primary outcome was change in the prevalence of delayed CINV. Secondary outcomes included acute prevalence of CINV, acute and delayed severity of CINV, and assessment of blinding.

Main results: There were no differences between groups in the prevalence of delayed nausea or vomiting, prevalence of acute CINV, or severity of delayed vomiting or acute nausea and vomiting. Participants who took both ginger and aprepitant had more severe acute nausea than participants who took only aprepitant. Participants were able to accurately guess which treatment they had received. Ginger appeared well tolerated, with no difference in all adverse events (AEs) and significantly less fatigue and miscellaneous AEs in the ginger group.

Conclusions: Ginger provides no additional benefit for reduction of the prevalence or severity of acute or delayed CINV when given with 5-HT3 receptor antagonists and/or aprepitant.

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Figures

Fig. 1
Fig. 1
Patient flow in the randomized controlled trial
See this image and copyright information in PMC

References

    1. Aeschbach R, Loliger J, Scott BC, et al. Antioxidant actions of thymol, carvacrol, 6-gingerol, zingerone and hydroxytyrosol. Food Chem Toxicol. 1994;32(1):31–36. doi:10.1016/0278-6915(84)90033-4. - PubMed
    1. Baranowski JD. High-performance liquid-chromatographic separation of pungency components of ginger. J Chromatogr A. 1985;319(3):471–474. doi:10.1016/S0021-9673(01)90593-X.
    1. Bloechl-Daum B, Deuson RR, Mavros P, Hansen M, Herrstedt J. Delayed nausea and vomiting continue to reduce patients’ quality of life after highly and moderately emetogenic chemotherapy despite antiemetic treatment. J Clin Oncol. 2006;24(27):4472–4478. doi:10.1200/JCO.2006.05.6382. - PubMed
    1. Chrubasik S, Pittler MH, Roufogalis BD. Zingiberis rhizoma: a comprehensive review on the ginger effect and efficacy profiles. Phytomedicine. 2005;12(9):684–701. doi:10.1016/j.phymed.2004.07.009. - PubMed
    1. Coates A, Abraham S, Kaye SB, et al. On the receiving end-patient perception of the side-effects of cancer chemotherapy. Eur J Cancer Clin Oncol. 1983;19(2):203–208. doi:10.1016/0277-5379(83)90418-2. - PubMed

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