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. 1998;5(2):75-82.
doi: 10.1007/BF02986390.

Antiestrogenic activity of anthropogenic and natural chemicals

J M Navas  1 , H Segner
Affiliations

Antiestrogenic activity of anthropogenic and natural chemicals

J M Navas et al. Environ Sci Pollut Res Int. 1998.

Abstract

A number of natural and man-made chemicals possess antiestrogenic activity, i.e. they antagonize a broad spectrum of estrogen-induced responses in vertebrates. Examples of antiestrogens include dioxin, furan and PCB congeners, certain PAHs, pesticides and indol-3-carbinol derivatives. Major mechanisms of anti-estrogenicity are antagonistic action of chemicals at the estrogen receptor, or binding of chemicals to the arylhydrocarbon (Ah) receptor and subsequent interaction with estrogen-responsive genes. Toxicological consequences resulting from antiestrogenic activity have not been conclusively demonstrated to date, although antiestrogenic compounds could critically affect sensitive reproductive and developmental processes.

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References

    1. Cell. 1989 Nov 3;59(3):477-87 - PubMed
    1. Mol Pharmacol. 1988 Jan;33(1):120-6 - PubMed
    1. Trends Endocrinol Metab. 1996 Nov;7(9):324-7 - PubMed
    1. Toxicol Appl Pharmacol. 1994 Jan;124(1):82-90 - PubMed
    1. Res Commun Chem Pathol Pharmacol. 1974 Sep;9(1):85-95 - PubMed