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. 2008 Dec 4;10(23):5489-92.
doi: 10.1021/ol802333n.

An organocatalytic approach to the construction of chiral oxazolidinone rings and application in the synthesis of antibiotic linezolid and its analogues

Lirong Song  1 , Xiaobei Chen, Shilei Zhang, Haoyi Zhang, Ping Li, Guangshun Luo, Wenjing Liu, Wenhu Duan, Wei Wang
Affiliations

An organocatalytic approach to the construction of chiral oxazolidinone rings and application in the synthesis of antibiotic linezolid and its analogues

Lirong Song et al. Org Lett. .

Abstract

An efficient, catalytic asymmetric approach to antibacterial agent linezolid has been developed. The route features organocatalytic, highly enantioselective aldol and Beckman rearrangement reactions. The strategy has also been successfully applied for the preparation of new alpha-substituted analogues with high enantio- and diastereoselectivity.

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