doi: 10.1021/jo801959j.
Vilsmeier reaction of enaminones: efficient synthesis of halogenated pyridin-2(1H)-ones
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- PMID: 19006368
- DOI: 10.1021/jo801959j
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Vilsmeier reaction of enaminones: efficient synthesis of halogenated pyridin-2(1H)-ones
J Org Chem.
.
Abstract
A facile and efficient one-pot synthesis of halogenated pyridin-2(1H)-ones from a series of readily available enaminones under Vilsmeier conditions is described, and a mechanism involving sequential halogenation, formylation, and intramolecular nucleophilic cyclization is proposed.
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