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. 2008 Dec 5;73(23):9504-7.
doi: 10.1021/jo801959j.

Vilsmeier reaction of enaminones: efficient synthesis of halogenated pyridin-2(1H)-ones

Rui Zhang  1 , Dingyuan Zhang, Yongli Guo, Guangyuan Zhou, Zijiang Jiang, Dewen Dong
Affiliations

Vilsmeier reaction of enaminones: efficient synthesis of halogenated pyridin-2(1H)-ones

Rui Zhang et al. J Org Chem. .

Abstract

A facile and efficient one-pot synthesis of halogenated pyridin-2(1H)-ones from a series of readily available enaminones under Vilsmeier conditions is described, and a mechanism involving sequential halogenation, formylation, and intramolecular nucleophilic cyclization is proposed.

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