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Comment
. 2008 Nov 14;29(5):665-7.
doi: 10.1016/j.immuni.2008.10.002.

A renaissance in understanding the multiple and diverse functions of granzymes?

Joseph A Trapani  1 , Phillip I Bird
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Free article
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A renaissance in understanding the multiple and diverse functions of granzymes?

Joseph A Trapani et al. Immunity. .
Free article

Abstract

In this issue of Immunity, Metkar et al. (2008) present evidence that granzyme A plays a role in inflammatory signaling and that contrary to previous studies, it is incapable of inducing target cell death. The work challenges us to reconsider the broader biological roles of all the granzymes.

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