Comment
doi: 10.1016/j.immuni.2008.10.005.
"Dangerous crystals"
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- PMID: 19006690
- DOI: 10.1016/j.immuni.2008.10.005
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Comment
"Dangerous crystals"
Immunity.
.
Free article
Abstract
Uric acid (UA) crystals are a potent stimulator of inflammation, but how they activate immune cells is not known. In this issue of Immunity, Ng et al. (2008) provide evidence suggesting that UA activates the Syk kinase via membrane cholesterol.
Comment on
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Receptor-independent, direct membrane binding leads to cell-surface lipid sorting and Syk kinase activation in dendritic cells.Immunity. 2008 Nov 14;29(5):807-18. doi: 10.1016/j.immuni.2008.09.013. Immunity. 2008. PMID: 18993083 Free PMC article.
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