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. 2009 Mar;130(3):298-303.
doi: 10.1016/j.clim.2008.10.001. Epub 2008 Nov 12.

The effect of aging on T-regulatory cell frequency in HIV infection

Allan R Tenorio  1 , John Spritzler, Jeffrey Martinson, Caroline N Gichinga, Richard B Pollard, Michael M Lederman, Robert C Kalayjian, Alan L Landay
Affiliations

The effect of aging on T-regulatory cell frequency in HIV infection

Allan R Tenorio et al. Clin Immunol. 2009 Mar.

Abstract

T-regulatory cell (T-reg) frequency is increased in HIV infection and with aging. We evaluated the effect of age on total, memory and naïve T-reg percentages in untreated HIV infection. Older HIV(+) subjects had a total T-reg percent that is 2.8% (p=0.02) higher than among younger HIV(+), older HIV(-) and younger HIV(-) subjects. In HIV(+) subjects, the total T-reg percentage is inversely correlated with the lymphocyte proliferative responses to tetanus (r=-0.45, p=0.002) and Candida (r=-0.43, p=0.003) antigens. Similar correlations were seen between memory T-reg percentages and the lymphocyte proliferative response to tetanus and Candida in HIV(+) subjects. T-reg percentages did not correlate consistently with markers of immune activation. T-reg percentages are increased in the older HIV(+) population and may play a role in the accelerated disease progression seen in older HIV-infected persons.

Trial registration: ClinicalTrials.gov NCT00006144 NCT00014053.

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Figures

Figure 1
Figure 1
Plot of age versus the total T-reg percent. Total T-reg percentage is defined as the percentage of CD4+ T-cells that are CD25+CD127lo. P represents HIV+ subjects while N represents HIV− subjects.
Figure 2
Figure 2
Plot of percentage of CD4+ T-cells that are CD25+CD127lo (total T-reg %) and the lymphocyte proliferative response to tetanus (A) and Candida albicans (B) in HIV+ subjects. Lymphoproliferation was assayed by measurement of [3H] thymidine incorporation in response to Candida albicans antigen (20 mg/mL; Greer Laboratories) and tetanus toxoid (2 limit-of-flocculation units [lfu]/mL; Aventis Pasteur). Results are expressed as the log10 of the stimulation index, defined as the ratio of the median counts per minute of quadruplicate cultures with antigen to the median counts per minute in culture medium alone without antigen.
Figure 2
Figure 2
Plot of percentage of CD4+ T-cells that are CD25+CD127lo (total T-reg %) and the lymphocyte proliferative response to tetanus (A) and Candida albicans (B) in HIV+ subjects. Lymphoproliferation was assayed by measurement of [3H] thymidine incorporation in response to Candida albicans antigen (20 mg/mL; Greer Laboratories) and tetanus toxoid (2 limit-of-flocculation units [lfu]/mL; Aventis Pasteur). Results are expressed as the log10 of the stimulation index, defined as the ratio of the median counts per minute of quadruplicate cultures with antigen to the median counts per minute in culture medium alone without antigen.
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