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Review
. 2009 Mar 27;284(13):8223-7.
doi: 10.1074/jbc.R800050200. Epub 2008 Nov 13.

SUMOylation and De-SUMOylation: wrestling with life's processes

Edward T H Yeh  1
Affiliations
Review

SUMOylation and De-SUMOylation: wrestling with life's processes

Edward T H Yeh. J Biol Chem. .

Abstract

The small ubiquitin-like modifier (SUMO) is a ubiquitin-like protein that covalently modifies a large number of cellular proteins. SUMO modification has emerged as an important regulatory mechanism for protein function and localization. SUMOylation is a dynamic process that is mediated by activating (E1), conjugating (E2), and ligating (E3) enzymes and readily reversed by a family of ubiquitin-like protein-specific proteases (Ulp) in yeast and sentrin/SUMO-specific proteases (SENP) in human. This review will focus on the de-SUMOylating enzymes with special attention to their biological function.

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Figures

FIGURE 1.
FIGURE 1.
SUMOylation and de-SUMOylation. SUMOylation is a dynamic process that is mediated by activating (E1), conjugating (E2), and ligating (E3) enzymes and readily reversed by the SENP family in human. SUMOylation and de-SUMOylation regulate a diverse spectrum of biological responses, from transcription, cell division, and signal transduction to carcinogenesis and viral replication.
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References

    1. Yeh, E. T., Gong, L., and Kamitani, T. (2000) Gene (Amst.) 248 1–14 - PubMed
    1. Hershko, A., Ciechanover, A., and Varshavsky, A. (2000) Nat. Med. 6 1073–1081 - PubMed
    1. Gong, L., Kamitani, T., Fujise, K., Caskey, L. S., and Yeh, E. T. (1997) J. Biol. Chem. 272 28198–28201 - PubMed
    1. Johnson, E. S., and Gupta, A. A. (2001) Cell 106 735–744 - PubMed
    1. Pichler, A., Gast, A., Seeler, J. S., Dejean, A., and Melchior, F. (2002) Cell 108 109–120 - PubMed

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