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Comment
. 2008 Dec;4(12):721-2.
doi: 10.1038/nchembio1208-721.

Seeing cellular sialidase transform sugars

Minoru Fukuda, Xingfeng Bao
Comment

Seeing cellular sialidase transform sugars

Minoru Fukuda et al. Nat Chem Biol. 2008 Dec.

Abstract

Cell-surface carbohydrates are synthesized in a step-wise fashion, yielding products with unique capping structures. A recent study has shown that carbohydrates at the cell surface can be further remodeled by an endogenous glycosidase to alter the carbohydrate structure, thus generating a new function.

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Figures

Figure 1
Figure 1
Biosynthetic pathway of mucin-like O-glycans. Once mucin-type O-glycans are synthesized in the Golgi by glycosyltransferases (GTs), the corresponding mucin-like glycoproteins are transported to the plasma membrane. Gadhoum and Sackstein showed that CD15s (sLex) on mucin-type glycoproteins is further subjected to processing by an endogenous sialidase on the cell surface, thus forming CD15 (Lex). Proteins are shown in light blue.
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References

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