Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2009 Jun;1793(6):941-6.
doi: 10.1016/j.bbamcr.2008.10.008. Epub 2008 Oct 29.

How Ca2+-ATPase pumps ions across the sarcoplasmic reticulum membrane

Chikashi Toyoshima  1
Affiliations
Free article
Review

How Ca2+-ATPase pumps ions across the sarcoplasmic reticulum membrane

Chikashi Toyoshima. Biochim Biophys Acta. 2009 Jun.
Free article

Abstract

Ca2+-ATPase of muscle sarcoplasmic reticulum is an ATP-powered Ca2+-pump that establishes a >10,000 fold concentration gradient across the membrane. Its crystal structures have been determined for 9 different states that cover nearly the entire reaction cycle. Presented here is a brief structural account of the ion pumping process, with emphasis on why the structure has to be so.

PubMed Disclaimer

Publication types

MeSH terms

LinkOut - more resources