Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2009 Feb 5;299(1):58-63.
doi: 10.1016/j.mce.2008.10.018. Epub 2008 Nov 1.

Dietary activators of Sirt1

Joanne S Allard  1 , Evelyn Perez, Sige Zou, Rafael de Cabo
Affiliations
Review

Dietary activators of Sirt1

Joanne S Allard et al. Mol Cell Endocrinol. .

Abstract

Calorie restriction (CR) is a non-genetic manipulation that reliably results in extended lifespan of several species ranging from yeast to dogs. The lifespan extension effect of CR has been strongly associated with an increased level and activation of the silent information regulator 2 (Sir2) histone deacetylase and its mammalian ortholog Sirt1. This association led to the search for potential Sirt1-activating, life-extending molecules. This review briefly outlines the experimental findings on resveratrol and other dietary activators of Sirt1.

PubMed Disclaimer

References

    1. Alvira D, Yeste-Velasco M, Folch J, Verdaguer E, Canudas AM, Pallas M, Camins A. Comparative analysis of the effects of resveratrol in two apoptotic models: inhibition of complex I and potassium deprivation in cerebellar neurons. Neuroscience. 2007;147:746–756. - PubMed
    1. Araki T, Sasaki Y, Milbrandt J. Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration. Science. 2004;305:1010–1013. - PubMed
    1. Asher G, Gatfield D, Stratmann M, Reinke H, Dibner C, Kreppel F, Mostoslavsky R, Alt FW, Schibler U. SIRT1 regulates circadian clock gene expression through PER2 deacetylation. Cell. 2008;134:317–328. - PubMed
    1. Banerjee S, Bueso-Ramos C, Aggarwal BB. Suppression of 7,12-dimethylbenz(a)anthracene-induced mammary carcinogenesis in rats by resveratrol: role of nuclear factor-kappaB, cyclooxygenase 2, and matrix metalloprotease 9. Cancer Res. 2002;62:4945–4954. - PubMed
    1. Bang HO. Dietary fish oils in the prevention and management of cardiovascular and other diseases. Compr Ther. 1990;16:31–35. - PubMed

Publication types

MeSH terms

LinkOut - more resources