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. 2009 Jan 1;19(1):259-63.
doi: 10.1016/j.bmcl.2008.10.118. Epub 2008 Nov 5.

Pyridine-3-carboxamides as novel CB(2) agonists for analgesia

William L Mitchell  1 , Gerard M P Giblin, Alan Naylor, Andrew J Eatherton, Brian P Slingsby, Anthony D Rawlings, Karamjit S Jandu, Carl P Haslam, Andrew J Brown, Paul Goldsmith, Nick M Clayton, Alex W Wilson, Iain P Chessell, Richard H Green, Andrew R Whittington, Ian D Wall
Affiliations

Pyridine-3-carboxamides as novel CB(2) agonists for analgesia

William L Mitchell et al. Bioorg Med Chem Lett. .

Abstract

We describe herein the medicinal chemistry approach which led to the discovery of a novel pyridine-3-carboxamide series of CB(2) receptor agonists. The SAR of this new template was evaluated and culminated in the identification of analogue 14a which demonstrated efficacy in an in vivo model of inflammatory pain.

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