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Review
. 2008 Nov 15;14(22):7159-60.
doi: 10.1158/1078-0432.CCR-08-2233.

Proliferation imaging to measure early cancer response to targeted therapy

David A Mankoff  1 , Janet F Eary
Affiliations
Review

Proliferation imaging to measure early cancer response to targeted therapy

David A Mankoff et al. Clin Cancer Res. .

Abstract

Positron emission tomography imaging using thymidine and analogues labeled with positron emitters provides noninvasive and quantitative estimates of regional cellular proliferation. This CCR Translations summary reviews the biological basis for proliferation imaging and discusses recent results using 18F-fluorothymidine-positron emission tomography to measure response to targeted therapy in the context of prior studies and potential future applications.

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