The protein structure initiative structural genomics knowledgebase

Abstract

The Protein Structure Initiative Structural Genomics Knowledgebase (PSI SGKB, http://kb.psi-structuralgenomics.org) has been created to turn the products of the PSI structural genomics effort into knowledge that can be used by the biological research community to understand living systems and disease. This resource provides central access to structures in the Protein Data Bank (PDB), along with functional annotations, associated homology models, worldwide protein target tracking information, available protocols and the potential to obtain DNA materials for many of the targets. It also offers the ability to search all of the structural and methodological publications and the innovative technologies that were catalyzed by the PSI's high-throughput research efforts. In collaboration with the Nature Publishing Group, the PSI SGKB provides a research library, editorials about new research advances, news and an events calendar to present a broader view of structural biology and structural genomics. By making these resources freely available, the PSI SGKB serves as a bridge to connect the structural biology and the greater biomedical communities.

Figure 1.

A functional view of the PSI SGKB resource. The PSI SGKB portal database is comprised of ID codes, sequences, external URLs and annotations. PDB ID, sequence, or keyword queries made to the PSI SGKB access other PSI data portals (TargetDB, PepcDB, PMP, Technology Portal, Publications Resource, MR, PSI Center websites), PDB and 50 other external biological resources (a selection is shown).