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Case Reports
. 1991 Apr;99(4):1025-6.
doi: 10.1378/chest.99.4.1025.

Amoxicillin-clavulanic acid for treating drug-resistant Mycobacterium tuberculosis

J P Nadler  1 , J Berger, J A Nord, R Cofsky, M Saxena
Affiliations
Case Reports

Amoxicillin-clavulanic acid for treating drug-resistant Mycobacterium tuberculosis

J P Nadler et al. Chest. 1991 Apr.

Abstract

This report describes two patients with multidrug resistant tuberculosis who were successfully treated with the addition of amoxicillin-clavulanic acid to second-line drugs. Mycobacterium tuberculosis possesses a beta-lactamase contributing to its resistance to beta-lactam antibiotics. The combination of clavulanic acid, a beta-lactamase inhibitor, and amoxicillin has been shown bactericidal for M tuberculosis in vitro. These data suggest that resistant tuberculosis may warrant a trial of treatment including amoxicillin-clavulanic acid.

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