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. 2009 Feb;160(2):333-7.
doi: 10.1111/j.1365-2133.2008.08922.x. Epub 2008 Nov 11.

Extranodal NK/T-cell lymphoma with cutaneous involvement: 'nasal' vs. 'nasal-type' subgroups--a retrospective study of 18 patients

Y-L Choi  1 , J-H Park, J-H Namkung, J-H Lee, J-M Yang, E-S Lee, D-Y Lee, K-T Jang, Y-H Ko
Affiliations

Extranodal NK/T-cell lymphoma with cutaneous involvement: 'nasal' vs. 'nasal-type' subgroups--a retrospective study of 18 patients

Y-L Choi et al. Br J Dermatol. 2009 Feb.

Abstract

Background: Extranodal natural killer T (NK/T) cell lymphoma is subcategorized into 'nasal' and 'nasal-type' NK/T-cell lymphomas according to the primary sites of anatomical involvement.

Objectives: The aim of this study was to characterize the cutaneous manifestations of the skin involving extranodal NK/T-cell lymphoma and to define the distinctive features of 'nasal' and 'nasal-type'. In addition, the prognostic factors that affect overall survival were investigated.

Methods: A retrospective case study of 18 patients with extranodal NK/T-cell lymphoma with cutaneous involvement was performed.

Results: The NK/T-cell lymphomas usually occurred in middle-aged, male patients. Most of the patients presented with either cellulitis or ulcer. A facial predilection for the location of the lesion was noted. The characteristic features of the 'nasal-type' compared with the 'nasal' were a localized involvement of the skin, less aggressive clinical course and better survival outcome.

Conclusions: Extranodal NK/T-cell lymphomas are extremely aggressive regardless of their subgroup. However, the 'nasal-type' NK/T-cell lymphoma was clinically less aggressive, more localized and had a better outcome compared with the other type. Cellulitis and ulcer were the major cutaneous manifestations.

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