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. 2008 Sep 29;1(1):2.
doi: 10.1186/1756-6614-1-2.

Metabolic and cardiovascular risk in patients with a history of differentiated thyroid carcinoma: A case-controlled cohort study

Massimo Giusti  1 , Lorenzo Mortara, Roberta Degrandi, Francesca Cecoli, Michele Mussap, Guido Rodriguez, Diego Ferone, Francesco Minuto
Affiliations

Metabolic and cardiovascular risk in patients with a history of differentiated thyroid carcinoma: A case-controlled cohort study

Massimo Giusti et al. Thyroid Res. .

Abstract

Hyperthyroidism seems to increase metabolic and cardiovascular risk, while the effects of sub-clinical hyperthyroidism are controversial. We evaluated metabolic and cardiovascular parameters in differentiated thyroid carcinoma (DTC) patients with suppressed thyrotropin (TSH) due to levo-thyroxine (L-T4) therapy. We studied DTC patients and, as a control group, patients with a history of surgery for non-malignant thyroid pathology. Significantly higher insulin and lower HDL-cholesterol levels were recorded in DTC subjects. In both groups, insulin levels were significantly related with body mass index (BMI) but not with age or L-T4 dosage. In DTC patients, a significant negative correlation was seen between HDL-cholesterol and BMI or L-T4 dosage. In both groups, intima-media thickness (IMT) correlated positively with age, BMI, glucose levels and systolic blood pressure. In DTC patients, increased IMT was significantly correlated with glycated hemoglobin (HbA1c), cholesterol and triglycerides. In DTC patients, C-reactive protein correlated positively with insulin, insulin resistance, triglycerides and systolic blood pressure, and negatively with HDL-cholesterol. In both DTC and control subjects, fibrinogen correlated positively with age, BMI, increased IMT, HbA1c and systolic blood pressure. In DTC subjects, plasma fibrinogen concentrations correlated positively with insulin resistance, cholesterol and LDL-cholesterol, and negatively with TSH levels. Our data confirm that the favorable evolution of DTC can be impaired by a high incidence of abnormal metabolic and cardiovascular data that are, at least in part, related to L-T4 therapy. These findings underline the need for adequate L-T4 titration.

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Figures

Figure 1
Figure 1
Correlation between TSH and fibrinogen levels in the cohort of subjects with DTC. While the number of pairs and significance for the analysis are reported, two experimental values of TSH above 5 mIU/L are not included in the graph.
See this image and copyright information in PMC

References

    1. Gorges R. The changing epidemiology of the thyroid cancer. In: Biersack H-J, Grunwald F, editor. Thyroid cancer. 2. Springer, Berlin; 2005. pp. 3–21.
    1. Belfiore A, La Rosa GL, La Porta GA, Giuffrida D, Milazzo G, Lupo L, Regalbuto C, Vigneri R. Cancer risk in patients with cold thyroid nodules: relevance of thyroid intake, sex, age and multinodularity. Am J Med. 1992;93:363–369. - PubMed
    1. Papini E, Guglielmi R, Bianchini A, Crescenzi A, Taccogna S, Nardi F, Panunzi C, Rinaldi R, Toscano V, Pacella CM. Risk of malignancy in non-palpable thyroid nodules: predictive value of ultrasound and color Doppler features. J Clin Endocrinol Metab. 2002;87:1941–1946. - PubMed
    1. Sidoti M, Marino G, Resmini E, Augeri C, Cappi C, Cavallero D, Lagasio C, Ceppa P, Minuto F, Giusti M. The rational use of fine needle aspiration biopsy (FNAB) in diagnosing thyroid nodules. Minerva Endocrinol. 2006;31:159–172. - PubMed
    1. Tuttle RM, Leboeuf R, Martorella AJ. Papillary thyroid cancer and therapy. Endocrinol Metab Clin N Am. 2007;36:753–778. - PubMed