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Review
. 2009 Feb;77(2):568-75.
doi: 10.1128/IAI.00832-08. Epub 2008 Nov 17.

Neutrophil recruitment to the lungs during bacterial pneumonia

Ann Craig  1 , John Mai, Shanshan Cai, Samithamby Jeyaseelan
Affiliations
Review

Neutrophil recruitment to the lungs during bacterial pneumonia

Ann Craig et al. Infect Immun. 2009 Feb.
No abstract available

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Figures

FIG. 1.
FIG. 1.
Schematic representation describing the cascade of events by which bacteria induce neutrophil sequestration and eventual lung damage associated with lower respiratory tract infection. Bacteria initially interact with the cells in the alveoli, including alveolar epithelial cells and macrophages (1), and induce the secretion of cytokines and neutrophil chemoattractants (2). These cytokines upregulate the expression of cell adhesion molecules on capillary endothelia (3) and subsequently mediate the transmigration of neutrophils into alveolar spaces based on the chemotactic gradient (4). The transmigrated neutrophils produce proteases, reactive oxygen species (ROS), and reactive nitrogen species (RNS) (5), which act on cells that are infected and induce necrotic cell death (6). Gradually, all of these events lead to extensive lung injury. RBCs, red blood cells.
See this image and copyright information in PMC

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