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. 2009 Jan;53(1):303-5.
doi: 10.1128/AAC.00901-08. Epub 2008 Nov 17.

International interlaboratory proficiency testing program for measurement of azole antifungal plasma concentrations

Roger J M Brüggemann  1 , Daan J Touw, Rob E Aarnoutse, Paul E Verweij, David M Burger
Affiliations

International interlaboratory proficiency testing program for measurement of azole antifungal plasma concentrations

Roger J M Brüggemann et al. Antimicrob Agents Chemother. 2009 Jan.

Abstract

An international interlaboratory proficiency testing program for the measurement of antifungal drugs was initiated in 2007. This first round was limited to azole antifungals: fluconazole, itraconazole and hydroxyitraconazole, voriconazole, and posaconazole. The results demonstrate the need for and utility of an ongoing proficiency testing program to further improve the analytical methods for routine patient management and clinical research.

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Figures

FIG. 1.
FIG. 1.
Deviation from the declared value. The horizontal solid lines represent the median value. The filled symbols indicate HPLC results, the unfilled symbols indicate LC-MS results, and the unfilled symbols with crosses indicate bioassay results. Four data points are outside the axis limits and are not shown in the graph: one laboratory reported ITZ at 17,595%, another laboratory reported hITZ at 126%, and a third laboratory reported 0.30 mg/liter posaconazole at 300% and 3.00 mg/liter posaconazole at 231%.
See this image and copyright information in PMC

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