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Review
. 2008 Dec;30(4):479-87.
doi: 10.1007/s00281-008-0138-z. Epub 2008 Nov 15.

Adoptive precursor cell therapy to enhance immune reconstitution after hematopoietic stem cell transplantation in mouse and man

Amanda M Holland  1 , Johannes L Zakrzewski, Gabrielle L Goldberg, Arnab Ghosh, Marcel R M van den Brink
Affiliations
Review

Adoptive precursor cell therapy to enhance immune reconstitution after hematopoietic stem cell transplantation in mouse and man

Amanda M Holland et al. Semin Immunopathol. 2008 Dec.

Abstract

Hematopoietic stem cell transplantation is a curative therapy for hematological malignancies. T cell deficiency following transplantation is a major cause of morbidity and mortality. In this review, we discuss adoptive transfer of committed precursor cells to enhance T cell reconstitution and improve overall prognosis after transplantation.

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Figures

Fig. 1
Fig. 1
Comparison of known stages of mouse and human T cell development in the thymus [, , , –83]
Fig. 2
Fig. 2
Proposed design for clinical use of “off-the-shelf” in vitro-derived T cell precursors for adoptive immunotherapy
See this image and copyright information in PMC

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