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Review
. 2008 Dec;23(12):1869-80.
doi: 10.1359/jbmr.081018.

Parathyroid carcinoma

Claudio Marcocci  1 , Filomena Cetani, Mishaela R Rubin, Shonni J Silverberg, Aldo Pinchera, John P Bilezikian
Affiliations
Review

Parathyroid carcinoma

Claudio Marcocci et al. J Bone Miner Res. 2008 Dec.
No abstract available

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Figures

FIG. 1
FIG. 1
HRPT2 mutations in sporadic parathyroid carcinomas. Mutations are designed according to the format generally used in the HRPT2 literature with single-letter amino acid codes. Mutations in bold are germinal.(36,37,45,46) *This mutation has been found in three unrelated kindreds.(36,37)
FIG. 2
FIG. 2
Immunohistochemical analysis of parafibromin expression. (Top) Normal parathyroid. A diffuse nuclear staining is present in most parathyroid cells (×200). (Middle) Parathyroid adenoma. The majority of cells show a positive nuclear staining (×400). (Bottom) Parathyroid carcinoma. Tumor cells show no nuclear staining (×200). (Reproduced from Eur J Endocrinol 156:547–554 with permission from the European Society of Endocrinology.)
FIG. 3
FIG. 3
Reduction in serum calcium concentration in parathyroid cancer with cincalcet. Subjects were given cinacalcet in increasing doses, up to 90 mg four times daily, during the titration phase. The average serum calcium fell from 14.5 ± 0.4 to 12.4 ± 0.4 mg/dl (p = 0.001). (Adapted from Silverberg SJ, Rubin MR, Faiman C, Peacock M, Shoback DM, Smallridge RC, Schwanauer LE, Olson KA, Klassen P, Bilezikian JP 2007 Cinacalcet hydrochloride reduces the serum calcium concentration in inoperable parathyroid carcinoma. J Clin Endocrinol Metab 92:3803–3808, Copyright 2007, The Endocrine Society.)
See this image and copyright information in PMC

References

    1. Shane E. Clinical review 122: Parathyroid carcinoma. J Clin Endocrinol Metab. 2001;2:485–493. - PubMed
    1. De Lellis RA. Parathyroid carcinoma. An overview. Adv Anat Pathol. 2005;12:53–61. - PubMed
    1. Cetani F, Pardi E, Banti C, Borsari S, Ambrogini E, Vignali E, Cianferotti L, Viccica G, Pinchera A, Marcocci C. HRPT2 gene analysis and diagnosis of parathyroid carcinoma. Expert Rev Endocrinol Metab. 2008;3:377–389. - PubMed
    1. Bondenson L, Grimelius L, DeLellis RA, Lloyd R, Akerstrom G, Larsson C, Arnold A, Eng C, Shane E, Bilezikian JP. Parathyroid carcinoma. In: DeLellis RA, Lloyd RV, Heitz PU, Eng C, editors. Pathology and Genetics. Tumors of Endocrine Organs. WHO Classification of Tumours. Lyon, France: IARC Press; 2004. pp. 124–127.
    1. Shane E. Parathyroid carcinoma. In: Bilezikian JP, Marcus R, Levine MA, editors. The Parathyroids. 2nd ed. Academic Press, San Diego, CA, USA: Basic and Clinical Concepts; 2001. pp. 515–525.

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