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Multicenter Study
. 2008 Dec 1;181(11):7944-7.
doi: 10.4049/jimmunol.181.11.7944.

Interaction between RANTES promoter variant and CCR5Delta32 favors recovery from hepatitis B

Chloe L Thio  1 , Jacquie Astemborski, Rasmi Thomas, Timothy Mosbruger, Mallory D Witt, James J Goedert, Keith Hoots, Cherie Winkler, David L Thomas, Mary Carrington
Affiliations
Multicenter Study

Interaction between RANTES promoter variant and CCR5Delta32 favors recovery from hepatitis B

Chloe L Thio et al. J Immunol. .

Abstract

Recovery from acute hepatitis B virus (HBV) infection occurs in 95% of adult-acquired infections. A 32-bp deletion in CCR5 (CCR5Delta32), which encodes for a nonfunctional receptor, increases the likelihood of recovery. Using 181 subjects with persistent HBV infection and 316 who had recovered, we tested the hypothesis that an epistatic interaction between functional polymorphisms in RANTES (a CCR5 ligand) and CCR5 impacts recovery. Specific models designed to assess individual contributions of compound genotypes demonstrated that the only combination associated with recovery from an HBV infection was RANTES -403A with CCR5Delta32 (odds ratio 0.36, p = 0.02). Because the phenotypic consequence of -403A is reported to be higher levels of RANTES, we propose a model in which excess RANTES in combination with low CCR5 favors recovery from an HBV infection, which will require validation through functional testing.

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Figures

Figure 1
Figure 1
Schematic diagram of RANTES gene and relative location of the coding regions (black boxes), untranslated regions (hashed boxes), and polymorphisms. The RANTES haplotypes are listed below the figure.
See this image and copyright information in PMC

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