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Review
. 2008 Dec;57(Pt 12):1445-1453.
doi: 10.1099/jmm.0.2008/003160-0.

Helicobacter pylori virulence and the diversity of gastric cancer in Asia

Lam Tung Nguyen  1   2 , Tomohisa Uchida  3   2 , Kazunari Murakami  1 , Toshio Fujioka  1 , Masatsugu Moriyama  2
Affiliations
Review

Helicobacter pylori virulence and the diversity of gastric cancer in Asia

Lam Tung Nguyen et al. J Med Microbiol. 2008 Dec.

Abstract

Infection with cagPAI positive strains of Helicobacter pylori is recognized as being associated with an increased risk of gastric cancer. This article reviews the current knowledge on the structures and pathological functions of cagPAI and the CagA protein, focusing especially on the molecular mechanism through which CagA may be involved in gastric carcinogenesis. The possible link between the geographical distribution of cagPAI and cagA variations and gastric cancer diversity in Asia is also discussed.

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