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. 2008:2:35-8.
doi: 10.2174/1874205X00802010035. Epub 2008 Jul 25.

Investigation between the S377G3 GATA-4 polymorphism and migraine

Chikhani Sherin  1 , Fernandez Francesca, Poetter Karl, Toohey Brendan, Harvey Ron, Griffiths Lyn
Affiliations

Investigation between the S377G3 GATA-4 polymorphism and migraine

Chikhani Sherin et al. Open Neurol J. 2008.

Abstract

Migraine is a common and painful neurological disorder, with genetic and environmental components. Several conditions have been shown to be comorbid with migraine, notably a cardiac malformation affecting the interatrial septum and leading to patent foramen ovale (PFO). Mutations in the development regulatory gene GATA-4, located on human chromosome 8p23.1-p22, have been found to be responsible for some cases of congenital heart defects including PFO. To determine whether the GATA-4 gene is involved in migraine, the present study performed an association analysis of a common GATA-4 variant that results in a change of amino acid (S377G), in a large case/control population (275 unrelated Caucasian migraineurs versus 275 control individuals). The results showed that there was no significant association for this polymorphism between migraine and controls (chi(2) = 0.84, P = 0.66). Thus it appears that the GATA-4 (S377G) mutation does not play a significant role in common migraine susceptibility.

Keywords: GATA 4 polymorphism; Heart disorder; Migraine; genetic association.

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References

    1. Breslau N, Rasmussen BK. The impact of migraine Epidemiology risk factors and co-morbidities. Neurology. 2001;56(6 Suppl 1):S4–12. - PubMed
    1. Cephalgia. Suppl 1. Vol. 24. 2004. HCCIHS Headache Classification Committee for the International Headache Society Classification and diagnostic criteria for headache disorders cranial neuralgias and facial pain 2nd edition; pp. 1–60. - PubMed
    1. Gervil M, Ulrich V, Kyvik KO, Olesen J, Russell MB. Migraine without aura a population-based twin study. Ann Neurol. 1999;46(4):606–11. - PubMed
    1. Montagna P. Molecular genetics of migraine headaches a review. Cephalalgia. 2000. pp. 3–14. - PubMed
    1. Bigal ME, Liberman JN, Lipton RB. Age-dependent prevalence and clinical features of migraine. Neurology. 2006;67(2):246–51. - PubMed

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