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. 2009 Jan-Feb;18(1):1-2.
doi: 10.1089/scd.2008.0304.

Cord blood stem cell therapy for acquired immune deficiency syndrome

Gabriel Gonzalez  1 , Elizabeth J Shpall, Joseph C Gathe, Richard R Behringer
Affiliations

Cord blood stem cell therapy for acquired immune deficiency syndrome

Gabriel Gonzalez et al. Stem Cells Dev. 2009 Jan-Feb.

Abstract

Cord blood stem cell transplantation is routinely used to treat hematopoietic diseases. Individuals who are homozygous for the 32 polymorphism of the CCR5 locus, encoding a co-receptor for HIV-1, are normal and are resistant to HIV infection. Here we suggest that public cord blood repositories are likely to contain CCR5 homozygous units that could be used as a therapy for HIV-infected individuals.

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References

    1. Dean M. Carrington M. Winkler C. Huttley GA. Smith MW. Allikmets R. Goedert JJ. Buchbinder SP. Vittinghoff E. Gomperts E. Donfield S. Vlahov D. Kaslow R. Saah A. Rinaldo C. Detels R Hemophilia Growth, Development Study, Multicenter AIDS Cohort Study, Multicenter Hemophilia Cohort Study, San Francisco City Cohort, ALIVE Study and SJ O'Brien. Genetic restriction of HIV-1 infection and progression to AIDS by a deletion allele of the CKR5 structural gene. Science. 1996;273:1856–1862. - PubMed
    1. Liu R. Paxton WA. Choe S. Ceradini D. Martin SR. Horuk R. MacDonald ME. Stuhlmann H. Koup RA. Landau NR. Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection. Cell. 1996;86:367–377. - PubMed
    1. Samson M. Libert F. Doranz BJ. Rucker J. Liesnard C. Farber CM. Saragosti S. Lapoumeroulie C. Cognaux J. Forceille C. Muyldermans G. Verhofstede C. Burtonboy G. Georges M. Imai T. Rana S. Yi Y. Smyth RJ. Collman RG. Doms RW. Vassart G. Parmentier M. Resistance to HIV-1 infection in caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene. Nature. 1996;382:722–725. - PubMed
    1. Kuhmann SE. Hartley O. Targeting chemokine receptors in HIV: a status report. Annu Rev Pharmacol Toxicol. 2008;48:425–461. - PubMed
    1. Martinson JJ. Chapman NH. Rees DC. Liu YT. Clegg JB. Global distribution of the CCR5 gene 32-basepair deletion. Nat Genet. 1997;16:100–103. - PubMed

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